課程資訊
課程名稱
應用生物統計學(甲)
Applied Biostatistics (A) 
開課學期
110-1 
授課對象
公共衛生學院  健康行為與社區科學研究所  
授課教師
張淑惠 
課號
EPM7006 
課程識別碼
849 M0900 
班次
 
學分
3.0 
全/半年
半年 
必/選修
必修 
上課時間
星期二2,3,4(9:10~12:10) 
上課地點
公衛214 
備註
流預所碩士班共同必修課程。公衛學院、統計碩士學位學程以外其它系所學生欲選修需經授課教師同意。與杜裕康合授
限碩士班以上 或 限公衛學院學生(含輔系、雙修生)
總人數上限:60人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/1101EPM7006_ 
課程簡介影片
 
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課程概述

This course consists of three parts: Part I consists of linear regression modeling and inferences, Part II generalized linear models and applications, and Part III advanced statistical methods. The main focus of this course is to understand the statistical methods, to learn how to undertake statistical analysis and how to interpret the results appropriately.
The course contains 2-hour lecture and 1-hour discussion section. The lecture will elaborate basic concepts and emphasize applications to public health and medicine. One-hour discussion section includes discussion of exercises, homework and results of data analysis. In the discussion section, the statistical software R is introduced and used to process data and prepare students for remaining course work in this sequence.
The basic calculus and linear algebra will be used to interpret the statistical theories and methods. Therefore, students need to have the mathematical knowledge and the ability of formula derivation.
 

課程目標
The aim of this course is to provide graduate students in medical campus to learn regression analysis, generalized linear modeling (GLM) for continuous, binary and count data; and advanced statistical methods including likelihood-based inferences, marginal and multilevel modeling approaches for longitudinal or multiple correlated outcomes to be able to analyze the various types of data for exploring and confirming the research hypotheses in the health-related sciences.
 
課程要求
Preliminary including elementary calculus and linear algebra. 
預期每週課後學習時數
 
Office Hours
另約時間 
指定閱讀
1. Regression Methods in Biostatistics. Linear, Logistic, Survival, and
Repeated Measures Models. Authors: Eric Vittinghoff, David V. Glidden, Stephen C. Shiboski, Charles E. McCulloch. Springer, 2012.
2. Multilevel analysis, 2nd edition. Author: Joop J Hox, New York: Routledge,
2010.
 
參考書目
1. Regression Methods in Biostatistics. Linear, Logistic, Survival, and
Repeated Measures Models. Authors: Eric Vittinghoff, David V. Glidden, Stephen
C. Shiboski, Charles E. McCulloch. Springer, 2012.
2. Basic Biostatistics, 2nd edition. Author: B Burt Gerstman. Burlington MA:
Jones & Bartlett Learning, 2015.
3. Extending the Linear Model with R: Julian Faraway. Boca Raton : Chapman &
Hall/CRC, 2006.
4. A Second Course in Statistics: Regression Analysis. William Mendenhall &
Terry Sincich. Prentice Hall, 2012
5. Introductory statistics with R. Authors: Peter Dalgaard. Springer- Verlag
New York, 2008
6. A handbook of statistical analyses using R, 2nd edition. Authors: Torsten
Hothorn & Brian Everitt, Boca Raton : Chapman & Hall/CRC, 2010
7. Multilevel analysis, 2nd edition. Author: Joop J Hox, New York: Routledge,
2010.  
評量方式
(僅供參考)
 
No.
項目
百分比
說明
1. 
期末考試 
35% 
 
2. 
期中考試 
35% 
 
3. 
作業及討論 
20% 
 
4. 
平時表現 
10% 
 
 
課程進度
週次
日期
單元主題
第01週
09/28  簡介/相關分析 (Introduction/Association analysis)
【使用Webex同步上課,課後提供上課錄影,欲加選同學可先寄信給助教或教師告知姓名和學號,助教會幫你加入旁聽】 
第02週
10/05  線性迴歸模型 (Linear regression models) (1)
【連結:https://ntucc.webex.com/ntucc/j.php?MTID=m412ec387675c2e165bcfc108d0d1f900】 
第03週
10/12  線性迴歸模型 (Linear regression models) (2) 
第04週
10/19  線性迴歸模型 (Linear regression models) (3) 
第05週
10/26  線性迴歸模型 (Linear regression models) (4) 
第06週
11/02  廣義線性迴歸模型 (Generalized linear models) (1) 
第07週
11/09  廣義線性迴歸模型 (Generalized linear models) (2) 
第08週
11/16  期中考試 (Midterm exam) 
第09週
11/23  廣義線性迴歸模型 (Generalized linear models) (3) 
第10週
11/30  多層次模型 (Multilevel models) (1) (杜裕康老師) 
第11週
12/07  多層次模型 (Multilevel models) (2) (杜裕康老師) 
第12週
12/14  多層次模型 (Multilevel models) (3) (杜裕康老師) 
第13週
12/21  多層次模型 (Multilevel models) (4) (杜裕康老師) 
第14週
12/28  長期追蹤資料分析 (Longitudinal data analysis) (1) 
第15週
2022/01/04  長期追蹤資料分析 (Longitudinal data analysis) (2) 
第16週
2022/01/11  期末考試 (Final exam)